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Missing proteins

1. Chromosome 1


Protein evidence according to NeXtProt for Chromosome 1:

2. Chromosome 2


Protein evidence according to NeXtProt for Chromosome 2:



3. Chromosome 3


Protein evidence according to NeXtProt for Chromosome 3:


Initial eveidence for proteins with NeXtProt level PE2
Q8N2R8 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.

4. Chromosome 4


Protein evidence according to NeXtProt for Chromosome 4:

5. Chromosome 5


Protein evidence according to NeXtProt for Chromosome 5:

6. Chromosome 6


Protein evidence according to NeXtProt for Chromosome 6:

7. Chromosome 7


Protein evidence according to NeXtProt for Chromosome 7:

8. Chromosome 8


Protein evidence according to NeXtProt for Chromosome 8:

9. Chromosome 9


Protein evidence according to NeXtProt for Chromosome 9:


Initial eveidence for proteins with NeXtProt level PE2
Q5VXU9 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.

10. Chromosome 10


Protein evidence according to NeXtProt for Chromosome 10:

11. Chromosome 11


Protein evidence according to NeXtProt for Chromosome 11:

12. Chromosome 12


Protein evidence according to NeXtProt for Chromosome 12:

13. Chromosome 13


Protein evidence according to NeXtProt for Chromosome 13:

14. Chromosome 14


Protein evidence according to NeXtProt for Chromosome 14:

15. Chromosome 15


Protein evidence according to NeXtProt for Chromosome 15:

16. Chromosome 16


Protein evidence according to NeXtProt for Chromosome 16:

17. Chromosome 17


Protein evidence according to NeXtProt for Chromosome 17:

18. Chromosome 18


Protein evidence according to NeXtProt for Chromosome 18:

Number of genes: 275
Number of proteins: 275
Number of validated proteins: 227
Number of proteins awaiting validation: 39
Number of uncertain proteins: 6

SourceEnsembl prot.-coding genesneXtProt entriesneXtProt PE1PeptideAtlasGPMdb greenHPA evid. supportiveOur data
Baseline*276272227195219175275
Missing005083581026
* from Lane et al., JPR, 2014 (cumulatively for different types of tissues and cell lines)


«In a broad sense, the scope of “missing” master proteins is restricted to unidentified proteins, which detection does not meet the gold threshold of neXtProt, the green threshold of GPMdb, the FDR of 1% at protein level in Peptide Atlas, or confident detection in Human ProteinAtlas».

In our understanding “missing” master proteins don't exist in separate tissue and cells, so these master proteins don't express in human body or cannot be detected due to the limitations of method sensitivity. Zgoda et al., JPR 2013

LIST OF ‘MISSING’ MASTER PROTEINS FOR CHR18 IN RESULTS OF OUR SRM PROTEOME PROFILING

GENEACProtein nameOur results of transcriptome profiling
LIVERHepG2 cell line
C18ORF64J3KSC0Putative uncharacterized protein encoded by LINC01387Not expressionNot expression
LDLRAD4O15165Low-density lipoprotein receptor class A domain-containing protein 4ExpressionExpression
PPP4R1Q8TF05Serine/threonine-protein phosphatase 4 regulatory subunit 1ExpressionExpression
ST8SIA5O15466Alpha-2,8-sialyltransferase 8EBelow thresholdsBelow thresholds
SERPINB10P48595Serpin B10Below thresholdsNot expression
TTC39CQ8N584Tetratricopeptide repeat protein 39CExpressionExpression

19. Chromosome 19


Protein evidence according to NeXtProt for Chromosome 19:


Initial eveidence for proteins with NeXtProt level PE2
Q14773 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.

20. Chromosome 20


Protein evidence according to NeXtProt for Chromosome 20:

21. Chromosome 21


Protein evidence according to NeXtProt for Chromosome 21:


Initial eveidence for proteins with NeXtProt level PE2
P57071 ProteomeXchange with ID PXD000434 from Lange, Huesgen et al.

22. Chromosome 22


Protein evidence according to NeXtProt for Chromosome 22:

23. Chromosome X


Protein evidence according to NeXtProt for Chromosome X:

24. Chromosome Y


Protein evidence according to NeXtProt for Chromosome Y:

25. Mitochondrial Chromosome


Protein evidence according to NeXtProt for Mitochondrial Chromosome: